Fossil fuels and petrochemicals may be making us sicker, research says

“These chemicals may be invisible, but they are having visible impacts.”

HOUSTON - Fossil fuel combustion and plastic production has increased more than 15 times since the 1950s and resulting exposure is linked to rising rates of cancer, neurodevelopmental issues and infertility, according to a new report.


The new research, published in the New England Journal of Medicine, highlights the concerns of chemicals derived from fossil fuels, specifically petrochemicals. Many of these are endocrine-disrupting chemicals, meaning they can disrupt the body’s hormones. Petrochemicals can be found everywhere: in plastic water bottles, water filters, clothing, furniture, cooking ware and more.

The rise of these chemicals coincides with more illness: In the U.S., rates of neurodevelopmental disorders, diabetes, chronic respiratory disease and cancer have increased between 28% and 150% between 1990 and 2019, according to the report.

This report is evident of correlation in which two things tend to occur at the same time and appear to not be by chance. However, it is not the same as causation and other types of studies would be required to prove causation.

“These chemicals may be invisible, but they are having visible impacts,” Tracey Woodruff, UC San Francisco professor and director of the EaRTH Center and Program on Reproductive Health and the Environment and author of the paper, told Environmental Health News (EHN).

It’s not just the U.S. Over the past seven decades, chronic health conditions have been on the rise worldwide, coinciding with the rise in plastic production and endocrine-disrupting chemicals. These chemicals can dysregulate hormones in different ways: they can alter the way hormones are built or how they move in the body and interfere hormone receptors.

The report notes a laundry list of health concerns associated with endocrine-disrupting chemical exposure: decreasing male sperm counts and harm to ovarian development, the development of metabolic disorders like obesity and diabetes, hormone-sensitive cancers, like breast or testicular cancer; and neurodevelopmental issues like lower IQs or attention deficit hyperactivity disorder, among others.

As plastic production is expected to nearly double by 2050, Woodruff and colleagues write that these issues are expected to worsen.

petrochemicals health

In addition, not everyone is equally exposed to these chemicals.. Communities of color are more likely to live at the fenceline of chemical facilities, increasing their exposure to fossil fuel and petrochemical pollution.

“These communities are also more likely to face other burdens like food insecurity, have lower incomes and insufficient access to medical care,” Woodruff said.

Woodruff said there are actions individuals can take to help decrease exposure. First, medical providers need to be more informed about the state of chemical regulation and their potential impacts on their patients’ health.

“Many clinicians are used to [the regulation of] pharmaceuticals,” Woodruff said. “If they are going to prescribe a drug to their patient, it is by law required to go through rigorous testing with animal studies as well as clinical trials. And it has to be proven both safe and efficacious before it can be prescribed to a patient.”

Additionally, Woodruff highlighted the need for reforms at the federal level.

“People think that the government is regulating everything and that’s not true,” Woodruff said. “It is really important for healthcare providers to speak out on behalf of their patients that there should be systemic change [for chemical regulation] through public policy, similar to pharmaceutical safety testing.”

A photo of a person texting on his phone with an image of comment bubbles with the words 'Hi Bot!'

Southern California air board rejected pollution rules after AI-generated flood of comments

An AI-powered platform generated at least 20,000 emails that helped defeat a proposal to phase out gas-powered appliances in Southern California, records show.

A flooded building with a metal roof

Floods linked to climate change hit nearly 1 million in Southern Africa

Devastating floods that swept across Southern Africa since December 2025, killing at least 280 people and affecting almost a million, were likely intensified by the impacts of climate change, scientists say.

the sun is setting over a lake with contrails in the sky

A case for avoiding contrails before we have all the answers

According to a comprehensive modeling study, the climate benefits of contrail avoidance depend on speed, not perfection.

A flooded mobile home park

A massive climate resilience program is escaping Florida’s DOGE purge

Ron DeSantis is slashing government spending, but the Sunshine State can’t afford to abandon its climate adaptation fund.
a factory with a lot of green and white generators on platforms outside

Lawmakers debate how to regulate data centers’ diesel backup generators

The use of data centers' diesel generators have become a flashpoint in communities concerned about the health impacts of the emissions.

Hospital lab scientist manipulating data on a computer

The climate impact of AI in healthcare

Chethan Sarabu, director of clinical innovation for the health tech hub at Cornell Tech, previews his HIMSS26 talk on AI's environmental impact and actions stakeholders can take to reduce it.

A closeup of a tailpipe with smoke coming out of it

Michigan health professionals say EPA Endangerment Finding repeal is a major hit to public health and climate action

The Environmental Protection Agency is overlooking the wide range of negative economic effects of allowing greenhouse gas emissions to run rampant, which directly hurt human health as a result of tailpipe pollution and contribute to more extreme weather events as the planet heats up.

From our Newsroom
Multiple Houston-area oil and gas facilities that have violated pollution laws are seeking permit renewals

Multiple Houston-area oil and gas facilities that have violated pollution laws are seeking permit renewals

One facility has emitted cancer-causing chemicals into waterways at levels up to 520% higher than legal limits.

Regulators are underestimating health impacts from air pollution: Study

Regulators are underestimating health impacts from air pollution: Study

"The reality is, we are not exposed to one chemical at a time.”

Pennsylvania governor Josh Shapiro speaks with the state flag and American flag behind him.

Two years into his term, has Gov. Shapiro kept his promises to regulate Pennsylvania’s fracking industry?

A new report assesses the administration’s progress and makes new recommendations

silhouette of people holding hands by a lake at sunset

An open letter from EPA staff to the American public

“We cannot stand by and allow this to happen. We need to hold this administration accountable.”

wildfire retardants being sprayed by plane

New evidence links heavy metal pollution with wildfire retardants

“The chemical black box” that blankets wildfire-impacted areas is increasingly under scrutiny.

Stay informed: sign up for The Daily Climate newsletter
Top news on climate impacts, solutions, politics, drivers. Delivered to your inbox week days.